FIG 3.

AGM and RM alternative coreceptors, GPR15 and CXCR6, can support entry by pseudotype viruses bearing SIVagm envelopes. Pseudotype reporter viruses bearing various SIVagm envelopes, including transmitted/founder (T/F) envelopes, were used to infect 293T target cells expressing AGM-derived (A) and RM-derived (B) coreceptors, i.e., CCR5, GPR15, and CXCR6. Pseudotype reporter viruses bearing vesicular stomatitis virus glycoprotein (VSV-g) served as a positive control. Infection was measured by the number of relative light units in cell lysates at 3 days postinfection. Graphs depict means and SD for representative experiments (n = 3).