FIG 3.

MMP408 administration reduced number of cells in BALF and inflammatory cells infiltrating around bronchioles and attenuated airway resistance induced by RSV infection. MMP408 was given after RSV infection (iMMP12-RSV) to inhibit MMP-12 expression, reducing the total number of cells, macrophages, and lymphocytes (A) and inflammatory cells (B) infiltrating around the bronchioles induced by RSV infection (magnification, ×200). (a) Control; (b) RSV; (c) iMMP12-RSV. (C) MMP408 administration attenuated AHR induced by RSV infection. Results are representative of two independent experiments, with a total of 5 to 7 mice/group, and all data are presented as means ± SEM. P < 0.05 (*), P < 0.01 (**), and P < 0.001 (***) compared to the control group; P < 0.05 (#) and P < 0.001 (###) compared to the RSV group. Tc, total cells; Mac, macrophages; Lym, lymphocytes; Neu, neutrophils.