FIG 4.

Degenerated PCFs suppressed MMP-12 production induced by RSV infection. MMP-12 expression around the bronchioles was suppressed in PCF-degenerated mice infected with RSV (KPCF-RSV) compared to that of intact mice infected with RSV (RSV) (magnification, ×100) and reduced the level of MMP-12 in BALF. (a) Control; (b) RSV; (c) KPCF control; (d) KPCF-RSV. (B) Level of MMP-12 in BALF. Results are representative of two independent experiments, with a total of 5 to 8 mice/group, and all data are presented as means ± SEM. **, P < 0.01 compared to the control; ##, P < 0.01 compared to the RSVd21 group; ^^, P < 0.01 compared to the KPCF control group.