TABLE 1.
Canonical pathways affected by 1918, 1918-like avian, and reassortant viruses
| Canonical pathway | P | Ratio |
|---|---|---|
| Cluster 1 “orange” (905 transcripts) | ||
| Communication between innate and adaptive immune cells | 1.60E–12 | 18/64 |
| Allograft rejection signaling | 3.78E–11 | 14/42 |
| Cross talk between dendritic cells and natural killer cells | 6.61E–10 | 16/69 |
| Autoimmune thyroid disease signaling | 2.27E–09 | 11/31 |
| GVHD signaling | 1.30E–07 | 10/35 |
| Cluster 2 “sky blue” (675 transcripts) | ||
| Glycolysis I | 1.82E–04 | 5/23 |
| Hepatic fibrosis/hepatic stellate cell activation | 1.91E–04 | 14/189 |
| Intrinsic prothrombin activation pathway | 4.03E–04 | 5/27 |
| TR/RXR activation | 1.31E–02 | 6/81 |
| Sucrose degradation V (mammalian) | 1.46E–02 | 2/8 |
| Cluster 3 “darkblue” (167 transcripts) | ||
| Cell cycle: G2/M DNA damage checkpoint regulation | 2.47E–12 | 10/49 |
| Mitotic roles of Polo-like kinase | 6.90E–10 | 9/61 |
| ATM signaling | 2.75E–07 | 7/59 |
| DNA damage-induced 14-3-3σ signaling | 2.32E–07 | 5/19 |
| GADD45 signaling | 1.06E–05 | 4/19 |
| Cluster 4 “black” (353 transcripts) | ||
| Granulocyte adhesion and diapedesis | 9.21E–13 | 18/151 |
| Interferon signaling | 6.53E–11 | 9/29 |
| Role of PRRs in recognition of bacteria and viruses | 2.84E–10 | 14/116 |
| Agranulocyte adhesion and diapedesis | 2.54E–09 | 15/161 |
| Dendritic cell maturation | 6.58E–09 | 14/147 |
| Cluster 5 “dark red” (103 transcripts) | ||
| LXR/RXR activation | 6.94E–05 | 5/108 |
| Role of PRRs in recognition of bacteria and viruses | 1.17E–03 | 4/116 |
| IL-10 signaling | 2.20E–03 | 3/65 |
| Role of hypercytokinemia/chemokinemia in the pathogenesis of influenza | 5.12E–03 | 2/27 |
| Role of RIG-I-like receptors in antiviral innate immunity | 6.30E–03 | 2/30 |
| Cluster 6 “yellow” (583 transcripts) | ||
| Calcium-induced T lymphocyte apoptosis | 1.64E–03 | 6/54 |
| B cell development | 1.88E–03 | 4/23 |
| Nur77 signaling in T lymphocytes | 4.81E–03 | 5/47 |
| Tight-junction signaling | 4.89E–03 | 10/161 |
| Autoimmune thyroid disease signaling | 5.77E–03 | 4/31 |
| Cluster 7 “red” (1,230 transcripts) | ||
| Retinol biosynthesis | 2.87E–04 | 7/29 |
| Tryptophan degradation X (mammalian, via tryptamine) | 6.05E–04 | 5/16 |
| Axonal guidance signaling | 6.39E–04 | 35/421 |
| Glutathione-mediated detoxification | 8.13E–04 | 6/25 |
| Ethanol degradation IV | 1.10E–03 | 5/18 |