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. 2016 Feb 16;5(3):323–335. doi: 10.1242/bio.015750

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Bj mutants show disruption of canonical Wnt signaling. (A,B) Analysis using the BAT-lacZ reporter showed increased lacZ reporter gene expression at the base of the outflow tract in the E13.5 Bj mutant heart (B) as compared to wild-type control (A). This suggests Wnt signaling is upregulated in the Bj mutant heart. Quantitative real-time PCR analysis (C) using RNA obtained from tissue isolated from the base of the OFT revealed changes in the expression of genes in both the canonical and noncanonical Wnt signaling pathway (D). Scale bar: 1 mm in A,B. The P values were calculated with Student's t-test; error bars show standard deviation.