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(a) Synthetic pathway for gemcitabine–poly(squalenyl methacrylate) (Gem-PSqMA) prodrug by reversible addition–fragmentation chain transfer (RAFT) polymerization. (b) DLS data giving the average diameter in intensity. (c) Cryo-TEM of Gem-PSqMA10 nanoparticles. The RAFT moiety was omitted on the schematic representation of the nanoparticle for clarity. Adapted with permissions from ref (68).
