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. 2016 Feb 21;28(6):1591–1606. doi: 10.1021/acs.chemmater.5b04281

Figure 17.

Figure 17

(a) Synthesis of 10-Boc-SN-38-poly(hydroxylpropyl methacrylamide) (10-Boc-SN-38-PHPMA) polymer prodrug by RAFT polymerization. (b) Apoptosis induction in a coculture of X63-Ag8 and L929 cells from SN-38 or SN-38-PHPMA polymer prodrugs after 48 h of incubation. The number of apoptotic/necrotic L929 cells (left) and apoptotic/necrotic X63-Ag8 cells (right) was determined using annexin-V (Ann.-V) and propidium iodide (PI) staining, and flow cytometry. Adapted with permissions from ref (61).