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The effect of ondansetron on the pharmacokinetic parameters of oral metformin in healthy men. (A) AUC. (B) V/F (oral volume of distribution; volume of distribution divided by oral bioavailability). (C) CL/F (oral clearance; clearance divided by oral bioavailability). (D) CLR (renal clearance). Statistical difference between the two treatments is indicated by the P values as shown.
