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. 2016 Apr;44(4):489–494. doi: 10.1124/dmd.115.067223

Fig. 3.

Fig. 3.

The effect of ondansetron on response to oral metformin in healthy men. (A) The 2-hour time course of plasma glucose concentrations for OGTT after metformin treatment in healthy men who received ondansetron or placebo treatment. Ondansetron (8 mg) or placebo was administrated at 8 PM daily for 5 days, and the last dose was taken at 7 AM in the sixth day. Metformin (850 mg) was then administered at 8 AM, and 75 g of glucose was given at 9 AM for a 2-hour OGTT. The data are expressed as mean ± S.E.M. *P < 0.05, ***P < 0.001 significant difference between the two treatments. (B) The glucose exposure with OGTT (AUC) after metformin administration in healthy men after ondansetron or placebo treatment. Ondansetron significantly decreased the AUC of OGTT in the healthy men as compared with placebo. *P ≤ 0.05, statistically different between the two treatments.