. Author manuscript; available in PMC: 2017 Apr 1.

Published in final edited form as: Psychol Med. 2016 Jan 20;46(5):1055–1067. doi: 10.1017/S0033291715002615

Table 3.

Group differences between single and multiple major depressive episodes compared with healthy controls using the PCC, amygdala and sgACC as seeds

		MNI coordinates
Contrast/lobe	BA	x	y	z	Z	Cluster size, mm³	Post-hoc comparison
Left PCC, F test group
Frontal
Middle frontal	9	−40	26	34	4.08	1440	Single > HC, multiple^a,b
Middle frontal	9/46	28	24	36	3.33	1272	Single > HC, multiple
Inferior frontal	46	−44	42	12	3.9	936	Single > HC^a,b
Inferior frontal	47/11	34	42	4	3.37	648	Single > HC, multiple^b
Parietal
Inferior parietal	22	52	−54	22	2.83	440	Single > multiple
Left amygdala, F test group
Frontal
Medial frontal	11	8	50	−16	4.13	7048	Single > HC, multiple^b
Middle frontal	11	38	40	−14	4.72	1392	Single > multiple^b
Middle frontal	6	42	18	52	3.54	1368	Single > multiple^b
Superior frontal	8	12	40	48	3.85	1024	Single > multiple
Superior frontal	8	−8	50	40	3.57	752	Single > multiple
Limbic
Uncus/amygdala	34	20	−4	−22	3.66	552	Single, multiple > HC
Temporal
Inferior temporal	20	68	−26	−16	4	616	Single > multiple
Occipital
Cuneus	18	−14	−98	18	3.48	608	HC > single, multiple
Inferior occipital	19	−38	−78	−2	3.42	504	HC > multiple^b
Subcortical
Caudate head		8	12	−2	3.86	1600	HC > multiple^b
Left sgACC, F test group
Frontal
Superior frontal	10	20	64	20	3.61	1072	HC < multiple
Inferior frontal	44/47	38	20	22	3.79	712	Single > multiple^b
Occipital
Middle occipital	18	−12	−98	22	3.98	528	HC, multiple > single^a

PCC, Posterior cingulate cortex; sgACC, subgenual anterior cingulate cortex; BA, Brodmann’s area; MNI, Montreal Neurological Institute; HC, healthy controls.

p < 0.05, within all major depressive disorder, significantly correlated with ^a the Hamilton Depression Scale and ^b age of first episode. No clusters are significantly correlated with the Hamilton Anxiety Scale.