Table 3.
MNI coordinates
|
|||||||
---|---|---|---|---|---|---|---|
Contrast/lobe | BA | x | y | z | Z | Cluster size, mm3 | Post-hoc comparison |
Left PCC, F test group | |||||||
Frontal | |||||||
Middle frontal | 9 | −40 | 26 | 34 | 4.08 | 1440 | Single > HC, multiplea,b |
Middle frontal | 9/46 | 28 | 24 | 36 | 3.33 | 1272 | Single > HC, multiple |
Inferior frontal | 46 | −44 | 42 | 12 | 3.9 | 936 | Single > HCa,b |
Inferior frontal | 47/11 | 34 | 42 | 4 | 3.37 | 648 | Single > HC, multipleb |
Parietal | |||||||
Inferior parietal | 22 | 52 | −54 | 22 | 2.83 | 440 | Single > multiple |
Left amygdala, F test group | |||||||
Frontal | |||||||
Medial frontal | 11 | 8 | 50 | −16 | 4.13 | 7048 | Single > HC, multipleb |
Middle frontal | 11 | 38 | 40 | −14 | 4.72 | 1392 | Single > multipleb |
Middle frontal | 6 | 42 | 18 | 52 | 3.54 | 1368 | Single > multipleb |
Superior frontal | 8 | 12 | 40 | 48 | 3.85 | 1024 | Single > multiple |
Superior frontal | 8 | −8 | 50 | 40 | 3.57 | 752 | Single > multiple |
Limbic | |||||||
Uncus/amygdala | 34 | 20 | −4 | −22 | 3.66 | 552 | Single, multiple > HC |
Temporal | |||||||
Inferior temporal | 20 | 68 | −26 | −16 | 4 | 616 | Single > multiple |
Occipital | |||||||
Cuneus | 18 | −14 | −98 | 18 | 3.48 | 608 | HC > single, multiple |
Inferior occipital | 19 | −38 | −78 | −2 | 3.42 | 504 | HC > multipleb |
Subcortical | |||||||
Caudate head | 8 | 12 | −2 | 3.86 | 1600 | HC > multipleb | |
Left sgACC, F test group | |||||||
Frontal | |||||||
Superior frontal | 10 | 20 | 64 | 20 | 3.61 | 1072 | HC < multiple |
Inferior frontal | 44/47 | 38 | 20 | 22 | 3.79 | 712 | Single > multipleb |
Occipital | |||||||
Middle occipital | 18 | −12 | −98 | 22 | 3.98 | 528 | HC, multiple > singlea |
PCC, Posterior cingulate cortex; sgACC, subgenual anterior cingulate cortex; BA, Brodmann’s area; MNI, Montreal Neurological Institute; HC, healthy controls.
p < 0.05, within all major depressive disorder, significantly correlated with a the Hamilton Depression Scale and b age of first episode. No clusters are significantly correlated with the Hamilton Anxiety Scale.