Table 4.
Unadjusted and adjusted β-coefficients for parameters of cardiovascular structure and function significantly different at univariable analyses by estimated glomerular filtration rate and urinary albumin-to-creatinine ratio combined categories
Normal UACR/preserved eGFR | High UACR /preserved eGFR | Normal UACR/low eGFR | High UACR/low eGFR | ||
---|---|---|---|---|---|
LVEDV (mL) | Reference | Unadjusted β-coefficient | 22.9** | 0.5 | 8.9 |
Adjusted β-coefficient | 13.9* | 3.4 | 1.0 | ||
LVESV (mL) | Reference | Unadjusted β-coefficient | 11.8** | −1.3 | 2.6 |
Adjusted β-coefficient | 6.3 | 0.3 | −2.7 | ||
SWT (cm) | Reference | Unadjusted β-coefficient | 0.07 | 0.13** | 0.09** |
Adjusted β-coefficient | 0.06 | 0.13** | 0.08* | ||
PWT (cm) | Reference | Unadjusted β-coefficient | 0.05 | 0.08** | 0.09** |
Adjusted β-coefficient | 0.03 | 0.08* | 0.06* | ||
LVM (g) | Reference | Unadjusted β-coefficient | 27** | 21** | 25** |
Adjusted β-coefficient | 16 | 22** | 15 | ||
LVMi (g/m2.7) | Reference | Unadjusted β-coefficient | 4.2** | 5.8** | 5.3** |
Adjusted β-coefficient | 3.6 | 4.5* | 4.3 | ||
RWT (cm) | Reference | Unadjusted β-coefficient | 0.000 | 0.041** | 0.035* |
Adjusted β-coefficient | −0.001 | 0.036* | 0.033 | ||
Cardiac output (L/min) | Reference | Unadjusted β-coefficient | 914** | 105 | 351 |
Adjusted β-coefficient | 712** | 322 | 276 | ||
MWFS (%) | Reference | Unadjusted β-coefficient | −0.25 | −1.20** | −0.82* |
Adjusted β-coefficient | −0.19 | −1.22** | −0.98* | ||
NT-proBNP (pg/mL) | Reference | Unadjusted β-coefficient | 148 | 341 | 840** |
Adjusted β-coefficient | 48 | 287 | 741** |
LVEDV, left ventricular end-diastolic volume; LVESV, left ventricular end-systolic volume; SWT, septal wall thickness; PWT, posterior wall thickness; LVM, left ventricular mass; LVMi, left ventricular mass indexed to height2.7; RWT, relative wall thickness; MWFS, midwall fractional shortening.
Adjusted for age, sex, PP, previous admission for HF, history of diabetes, anaemia.
*P < 0.05 for comparison vs. reference (both eGFR and UACR normal).
**P < 0.01 for comparison vs. reference (both eGFR and UACR normal).