Table 3.
Effect of SAL (300 mg/kg) on the major biomarkers of liver in APAP model.
| Group | Material dose (mg/kg) | N | Survival rate | Analyte | ||||
|---|---|---|---|---|---|---|---|---|
| AST (U/L) | Bile acid (μmol/L) | T. bilirubin (mg/dL) | Albumin (g/dL) | T. protein (g/dL) | ||||
| Control | 0 | 10 | 100 | 77.7 ± 28.3 | 1.0 + 0.0 | 0.1 + 0.0 | 2.67 + 0.09 | 4.70 + 0.24 |
| APAP (400 mg/kg) | 0 | 10 | 60 | 4707.7 ± 2899.1 | 76.2 + 24.8 | 0.5 + 0.2 | 2.33 + 0.20 | 4.43 + 0.22 |
| SAL | 300 | 10 | 90 | 1855.7 ± 1859.6∗ | 15.1 + 5.7∗ | 0.3 + 0.1∗ | 2.71 + 0.12∗ | 4.84 + 0.12∗ |
Mice (n = 10) were orally given composition SAL at doses of 300 mg/kg at −48 hr, −24 hr, and −2 hr before APAP administrations and +6 hr after induction of model suspended in 10% Tween-20. Hepatotoxicity models were induced using 400 mg/kg APAP administered orally. Serum was collected at T24. Data are expressed as mean ± SD. ∗ p ≤ 0.05.