TABLE 1.
SNP | Phenotype | Chr | Min/Maj | MAF | PPC | WF | CS | MLU | SPE | P | Gene | Variant Type |
---|---|---|---|---|---|---|---|---|---|---|---|---|
rs722208 | All | 6q25 | G/A | 0.35 | 0.38 | 0.18 | −0.17 | 0.08 | 0.22 | 3.09 × 10−6 | ESR1 | Intron |
rs1559831 | All | 15q14 | T/C | 0.06 | −0.17 | −0.64 | 0.65 | 0.17 | −0.34 | 3.81 × 10−6 | Intergenic | |
rs6496012 | All | 15q14 | G/A | 0.06 | −0.17 | −0.64 | 0.65 | 0.17 | −0.34 | 3.81 × 10−6 | Intergenic | |
rs3787751 | All | 21q22 | C/T | 0.05 | −0.16 | −0.39 | 0.04 | 0.04 | −0.07 | 4.88 × 10−6 | HLCS | Intron |
rs639373 | All | 11q23 | C/T | 0.38 | 0.30 | 0.08 | 0.19 | 0.05 | −0.10 | 1.37 × 10−5 | C2CD2L | Upstream |
rs2180386 | All | 14q32 | A/C | 0.38 | −0.35 | −0.27 | 0.05 | −0.11 | −0.22 | 1.60 × 10−5 | MEG8 | Intron |
rs780382 | All | 11p15 | A/G | 0.42 | −0.26 | −0.04 | 0.22 | 0.09 | −0.04 | 1.89 × 10−5 | SBF2 | Intron |
rs585149 | All | 11q23 | T/C | 0.16 | 0.16 | 0.23 | −0.02 | 0.45 | 0.16 | 2.83 × 10−5 | SIK2, PPP2R1B | UTR′-3 |
rs8066993 | All | 17q25 | T/C | 0.21 | −0.06 | −0.36 | 0.15 | −0.21 | 0.00 | 2.90 × 10−5 | RNF213 | Intron |
rs2183850 | All | 13q34 | A/G | 0.48 | 0.03 | 0.04 | 0.28 | 0.21 | 0.16 | 2.98 × 10−5 | ||
rs3789868 | Syn. comp. | 9q33 | G/A | 0.47 | — | — | 0.06 | −0.34 | — | 3.81 × 10−6 | TNC | Intron |
rs3789867 | Syn. comp. | 9q33 | T/G | 0.47 | — | — | 0.05 | −0.35 | — | 4.02 × 10−6 | TNC | Intron |
rs2480933 | Syn. comp. | 9q33 | A/G | 0.46 | — | — | 0.06 | −0.34 | — | 5.51 × 10−6 | TNC | Intron |
rs2482078 | Syn. comp. | 9q33 | A/G | 0.42 | — | — | 0.05 | −0.33 | — | 6.57 × 10−6 | TNC | Intron |
rs2011604 | Syn. comp. | 14q32 | T/C | 0.43 | — | — | 0.11 | −0.30 | — | 1.25 × 10−5 | Intergenic | |
rs585149 | Syn. comp. | 11q23 | T/C | 0.16 | — | — | −0.01 | 0.45 | — | 1.70 × 10−5 | SIK2, PPP2R1B | |
rs2893567 | Syn. comp. | 7p14-p13 | G/A | 0.27 | — | — | 0.23 | −0.28 | — | 2.04 × 10−5 | VPS41 | Intron |
rs1537722 | Syn. comp. | 9q33 | T/C | 0.36 | — | — | −0.03 | 0.33 | — | 2.62 × 10−5 | ||
rs4796604 | Syn. comp. | 17q21 | T/C | 0.44 | — | — | 0.36 | 0.04 | — | 2.96 × 10−5 | HAP1 | Missense |
rs2699376 | Syn. comp. | 2q14 | T/C | 0.19 | — | — | 0.07 | −0.39 | — | 3.15 × 10−5 | CNTNAP5 | Intron |
rs3787751 | Ling. err. | 21q22 | C/T | 0.45 | −0.16 | −0.39 | — | — | −0.07 | 5.35 × 10−7 | HLCS | Intron |
rs10504229 | Ling. err. | 8q12 | A/G | 0.16 | 0.25 | 0.25 | — | — | 0.50 | 5.59 × 10−6 | LINC00588 | Intron |
rs2180386 | Ling. err. | 14q32 | A/G | 0.38 | −0.33 | −0.27 | — | — | −0.21 | 7.37 × 10−6 | MEG8 | Intron |
rs12121864 | Ling. err. | 1p36 | C/A | 0.09 | 0.64 | 0.14 | — | — | 0.28 | 8.00 × 10−6 | Intergenic | |
rs10486031 | Ling. err. | 7p21 | G/A | 0.16 | 0.33 | −0.05 | — | — | −0.32 | 1.06 × 10−5 | DGKB | Intron |
rs639373 | Ling. err. | 11q23 | C/T | 0.38 | 0.31 | 0.08 | — | — | −0.09 | 1.21 × 10−5 | C2CD2L | Upstream |
rs643788 | Ling. err. | 11q23 | T/C | 0.41 | 0.32 | 0.11 | — | — | −0.06 | 1.22 × 10−5 | DPAGT1, H2AFX | Missense |
rs17445063 | Ling. err. | 20q13 | G/T | 0.11 | 0.29 | 0.53 | — | — | 0.09 | 2.16 ×10−5 | Intergenic | |
rs722208 | Ling. err. | 6q25 | G/A | 0.35 | 0.37 | 0.18 | — | — | 0.22 | 2.48 ×10−5 | ESR1 | Intron |
rs4895970 | Ling. err. | 6q23 | T/C | 0.50 | 0.36 | 0.15 | — | — | 0.14 | 2.75 ×10−5 | Intergenic |
Coefficients for phonetic/prosodic characteristics (PPC), well-formedness (WF), complex structures (CS), mean length of utterance (in words) (MLU), and semantic/pragmatic errors (SPE) represent effect size estimates (regression coefficients in SD units) for the minor allele. Chr, chromosomal location (cytoband); Ling. err, linguistic errors; MAF, minor allele frequency; Min/Maj, minor/major allele; Syn. comp., syntactic complexity; — coefficient was not estimated in the analysis and is not available.