TABLE 1.

Top 10 Nominally Significant SNP Associations for Each of the 3 Multivariate GWAS Analyses

SNP	Phenotype	Chr	Min/Maj	MAF	PPC	WF	CS	MLU	SPE	P	Gene	Variant Type
rs722208	All	6q25	G/A	0.35	0.38	0.18	−0.17	0.08	0.22	3.09 × 10−6	ESR1	Intron
rs1559831	All	15q14	T/C	0.06	−0.17	−0.64	0.65	0.17	−0.34	3.81 × 10−6		Intergenic
rs6496012	All	15q14	G/A	0.06	−0.17	−0.64	0.65	0.17	−0.34	3.81 × 10−6		Intergenic
rs3787751	All	21q22	C/T	0.05	−0.16	−0.39	0.04	0.04	−0.07	4.88 × 10−6	HLCS	Intron
rs639373	All	11q23	C/T	0.38	0.30	0.08	0.19	0.05	−0.10	1.37 × 10−5	C2CD2L	Upstream
rs2180386	All	14q32	A/C	0.38	−0.35	−0.27	0.05	−0.11	−0.22	1.60 × 10−5	MEG8	Intron
rs780382	All	11p15	A/G	0.42	−0.26	−0.04	0.22	0.09	−0.04	1.89 × 10−5	SBF2	Intron
rs585149	All	11q23	T/C	0.16	0.16	0.23	−0.02	0.45	0.16	2.83 × 10−5	SIK2, PPP2R1B	UTR′-3
rs8066993	All	17q25	T/C	0.21	−0.06	−0.36	0.15	−0.21	0.00	2.90 × 10−5	RNF213	Intron
rs2183850	All	13q34	A/G	0.48	0.03	0.04	0.28	0.21	0.16	2.98 × 10−5
rs3789868	Syn. comp.	9q33	G/A	0.47	—	—	0.06	−0.34	—	3.81 × 10−6	TNC	Intron
rs3789867	Syn. comp.	9q33	T/G	0.47	—	—	0.05	−0.35	—	4.02 × 10−6	TNC	Intron
rs2480933	Syn. comp.	9q33	A/G	0.46	—	—	0.06	−0.34	—	5.51 × 10−6	TNC	Intron
rs2482078	Syn. comp.	9q33	A/G	0.42	—	—	0.05	−0.33	—	6.57 × 10−6	TNC	Intron
rs2011604	Syn. comp.	14q32	T/C	0.43	—	—	0.11	−0.30	—	1.25 × 10−5		Intergenic
rs585149	Syn. comp.	11q23	T/C	0.16	—	—	−0.01	0.45	—	1.70 × 10−5	SIK2, PPP2R1B
rs2893567	Syn. comp.	7p14-p13	G/A	0.27	—	—	0.23	−0.28	—	2.04 × 10−5	VPS41	Intron
rs1537722	Syn. comp.	9q33	T/C	0.36	—	—	−0.03	0.33	—	2.62 × 10−5
rs4796604	Syn. comp.	17q21	T/C	0.44	—	—	0.36	0.04	—	2.96 × 10−5	HAP1	Missense
rs2699376	Syn. comp.	2q14	T/C	0.19	—	—	0.07	−0.39	—	3.15 × 10−5	CNTNAP5	Intron
rs3787751	Ling. err.	21q22	C/T	0.45	−0.16	−0.39	—	—	−0.07	5.35 × 10−7	HLCS	Intron
rs10504229	Ling. err.	8q12	A/G	0.16	0.25	0.25	—	—	0.50	5.59 × 10−6	LINC00588	Intron
rs2180386	Ling. err.	14q32	A/G	0.38	−0.33	−0.27	—	—	−0.21	7.37 × 10−6	MEG8	Intron
rs12121864	Ling. err.	1p36	C/A	0.09	0.64	0.14	—	—	0.28	8.00 × 10−6		Intergenic
rs10486031	Ling. err.	7p21	G/A	0.16	0.33	−0.05	—	—	−0.32	1.06 × 10−5	DGKB	Intron
rs639373	Ling. err.	11q23	C/T	0.38	0.31	0.08	—	—	−0.09	1.21 × 10−5	C2CD2L	Upstream
rs643788	Ling. err.	11q23	T/C	0.41	0.32	0.11	—	—	−0.06	1.22 × 10−5	DPAGT1, H2AFX	Missense
rs17445063	Ling. err.	20q13	G/T	0.11	0.29	0.53	—	—	0.09	2.16 ×10−5		Intergenic
rs722208	Ling. err.	6q25	G/A	0.35	0.37	0.18	—	—	0.22	2.48 ×10−5	ESR1	Intron
rs4895970	Ling. err.	6q23	T/C	0.50	0.36	0.15	—	—	0.14	2.75 ×10−5		Intergenic

Coefficients for phonetic/prosodic characteristics (PPC), well-formedness (WF), complex structures (CS), mean length of utterance (in words) (MLU), and semantic/pragmatic errors (SPE) represent effect size estimates (regression coefficients in SD units) for the minor allele. Chr, chromosomal location (cytoband); Ling. err, linguistic errors; MAF, minor allele frequency; Min/Maj, minor/major allele; Syn. comp., syntactic complexity; — coefficient was not estimated in the analysis and is not available.