TABLE 1.
Characteristics of RIVUR Subjects by rUTIs
| Overall, n = 571, n (%) | No rUTI, n = 470, n (%) | At Least 1 Resistant rUTI, n = 45, n (%) | Subjects With Only Susceptible rUTIs, n = 56, n (%) | Overall Pa | R vs S Pb | |
|---|---|---|---|---|---|---|
| Total no. of patients | <.001 | <.001 | ||||
| TMP-SMX | 278 (49) | 244 (52) | 26 (58) | 8 (14) | ||
| Placebo | 293 (51) | 226 (48) | 19 (42) | 48 (86) | ||
| Age at enrollment, mo | .01 | .90 | ||||
| <12 | 275 (48) | 233 (50) | 19 (42) | 23 (41) | ||
| 12–35 | 179 (31) | 154 (33) | 12 (27) | 13 (23) | ||
| 36–72 | 117 (20) | 83 (18) | 14 (31) | 20 (36) | ||
| Gender | .35 | .32 | ||||
| Circumcised boys | 17 (3) | 17 (4) | 0 (0) | 0 (0) | ||
| Girls | 526 (92) | 429 (91) | 42 (93) | 55 (98) | ||
| Uncircumcised boys | 28 (5) | 24 (5) | 3 (7) | 1 (2) | ||
| Race | .05 | .03 | ||||
| Nonwhite | 113 (20) | 96 (21) | 12 (27) | 5 (9) | ||
| White | 448 (80) | 364 (79) | 33 (73) | 51 (91) | ||
| Hispanic ethnicity | .63 | .75 | ||||
| Hispanic | 75 (13) | 65 (14) | 5 (11) | 5 (9) | ||
| Other | 493 (87) | 402 (86) | 40 (89) | 51 (91) | ||
| Highest VUR grade | .32 | >.99 | ||||
| I | 62 (11) | 52 (11) | 4 (9) | 6 (11) | ||
| II | 244 (43) | 211 (45) | 15 (33) | 18 (33) | ||
| III | 218 (38) | 172 (37) | 21 (47) | 25 (45) | ||
| IV | 44 (8) | 33 (7) | 5 (11) | 6 (11) | ||
| VUR laterality | .93 | >.99 | ||||
| Bilateral | 271 (48) | 225 (48) | 20 (45) | 26 (47) | ||
| Unilateral | 292 (52) | 239 (52) | 24 (55) | 29 (53) | ||
| Index UTI organism | .66 | .92 | ||||
| E coli | 509 (89) | 417 (89) | 41 (91) | 51 (91) | ||
| Enterococcus species | 13 (2) | 12 (3) | 1 (2) | 0 (0) | ||
| Klebsiella species | 18 (3) | 15 (3) | 1 (2) | 2 (4) | ||
| Proteus species | 14 (2) | 14 (3) | 0 (0) | 0 (0) | ||
| Other | 17 (3) | 12 (3) | 2 (4) | 3 (5) | ||
| Index UTI symptoms | .50 | .41 | ||||
| Febrile | 490 (86) | 405 (86) | 36 (80) | 49 (88) | ||
| Nonfebrile | 81 (14) | 65 (14) | 9 (20) | 7 (13) | ||
| Index UTI | .21 | .16 | ||||
| Resistant | 120 (21) | 96 (20) | 14 (31) | 10 (18) | ||
| Susceptible | 451 (79) | 374 (80) | 31 (69) | 46 (82) | ||
| BBD | .003 | .83 | ||||
| No BBD | 54 (10) | 42 (9) | 6 (14) | 6 (11) | ||
| BBD | 68 (12) | 45 (10) | 9 (20) | 14 (25) | ||
| Not toilet trained | 441 (78) | 376 (81) | 29 (66) | 36 (64) | ||
| History of constipation | .72 | .82 | ||||
| No | 401 (71) | 326 (70) | 34 (76) | 41 (73) | ||
| Yes | 166 (29) | 140 (30) | 11 (24) | 15 (27) | ||
| Treated for constipation | .72 | .75 | ||||
| No | 491 (87) | 401 (86) | 41 (91) | 49 (88) | ||
| Yes | 76 (13) | 65 (14) | 4 (9) | 7 (13) | ||
| No. of rUTIsc | ||||||
| 0 | 470 (82) | 470 (100) | 0 (0) | 0 (0) | ||
| 1 | 64 (11) | 0 (0) | 26 (58) | 38 (68) | ||
| 2 | 27 (5) | 0 (0) | 12 (27) | 15 (27) | ||
| 3 | 5 (1) | 0 (0) | 4 (9) | 1 (2) | ||
| 4 | 5 (1) | 0 (0) | 3 (7) | 2 (4) |
a
P values for an overall comparison of no rUTI, at least 1 resistant UTI, and only susceptible UTIs were computed using Fisher's exact test.
b
P value for a comparison of at least 1 resistant UTI versus only susceptible UTIs using Fisher's exact test.
c
P values were not computed for number of rUTIs.