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. Author manuscript; available in PMC: 2016 Mar 29.
Published in final edited form as: Science. 2016 Jan 21;351(6274):aad5510. doi: 10.1126/science.aad5510

Fig. 4. Self-renewal genes are associated with distinct enhancers in ES cells and macrophages.

Fig. 4

A) Genomic regions surrounding MYC, KLF2 and KLF4 genes showing distinct ES cell (blue) and macrophage (red) specific predicted enhancer regions with differential H3K27ac and p300 enrichment in Maf-DKO over WT BMM (red boxes). B) Heatmaps and k-means clustering (k=2) of Chip-seq signal of all H3K27ac+ regions associated with self-renewal genes in ES cells, Maf-DKO and WT BMM, including both differentially regulated Maf-DKO-only and non-differentially regulated regions. Corresponding regions are shown for p300, H3K4m1 and PU.1 (ES, Maf-DKO and WT BMM). C) Model based on panels A) and B) to describe tissue-specific macrophage and ES cell enhancer platforms associated with individual self-renewal genes.