Figure 1. Log-odds compatibility scores relating amino acids to native state ensemble-based thermodynamic environments.

These scores were computed as previously described [29–31] using the amino acids and thermodynamic environments data given in Table S2. A positive value indicates that the amino acid is found more often than expected in a particular thermodynamic environment within globular proteins, while a negative value indicates occurrence less often than expected. Colors are identical to those used in Figures 4 and 5, i.e. violet, blue, green are lower predicted stability and yellow, orange red are higher stability.