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. 2016 Feb 25;1(2):e85562. doi: 10.1172/jci.insight.85562

Figure 6. Comparison of T antigen and VP1 immunostaining of known human polyomaviruses.

Figure 6

T antigen and virus-specific VP1 staining in (A) Merkel cell polyomavirus (MCV-positive) Merkel cell carcinoma (MCC), (B) human polyomavirus 7–positive (HPyV7-positive) skin rash, and (C) trichodysplasia-spinulosa virus-positive (TSV-positive) trichodysplasia spinulosa (TS) tissue. For T antigen staining, a triple antibody combination of PAb416, Xt7, and 2t2 was used. For VP1 staining, virus-specific antibodies CM9B2, 6V32, and TSV-VP1 were used for MCV, HPyV7, and TSV, respectively. MCV-positive tumors positive for T antigen do not express VP1. HPyV7-positive skin rash shows cytoplasmic, intercellular, and some nuclear VP1 expression and scattered T antigen expression in the epidermis. TSV T antigen is more broadly expressed in contrast to VP1 in the TS lesion. Original magnification, ×10.