Table 3. Mixed models analysis of determinants of systolic (SBP) and diastolic blood pressure (DBP) trajectory during pregnancy, corrected for baseline BP^a.

	SBP			DBP
Adjustedb	Estimate	95% CI	P	Estimate	95% CI	P
25(OH)D T1 (nmol/L)	0.020	>0.00–0.04	0.02	0.009	<0.00–0.02	0.158
BMI ≥30 T1	-4.298	-5.80–-2.81	<0.001	-4.444	-5.60–-3.29	<0.001
Nulliparity	1.901	1.14–2.66	<0.001	1.903	1.32–2.49	<0.001
Preexisting medical condition T1	1.245	-0.07–2.56	0.063	0.812	-0.20–1.83	0.117
Age ≥40 years T1	0.682	-1.11–2.48	0.456	0.169	-1.22–1.55	0.811
Assisted reproduction	-0.792	-2.47–0.89	0.356	-0.613	-1.91–0.68	0.354
Height (cm) T1	-0.138	-0.20–-0.07	<0.001	-0.164	-0.21–-0.11	<0.001
Weight trajectory (kg)	0.278	0.242–0.31	<0.001	0.246	0.22–0.27	<0.001

SBP = systolic blood pressure, DBP = diastolic blood pressure, 25(OH)D = 25-hydroxyvitamin D, T1 = first trimester, BMI = body mass index. Reference categories for dichotomous variables are baseline BMI<30, parous, no preexisting medical condition, age <40 years, no tobacco use and no assisted reproduction. Weight, 25(OH)D and height are continuous.

^a. Blood pressure at 3 time points (gestational week 25, 32 and 37), adjusted for blood pressure at baseline (week 10)

^b. Adjusted for baseline SBP or DBP, multifetal pregnancy, Northern European birth country, baseline employment status, gestational age at baseline, month of conception and baseline tobacco use