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. 2015 Dec 19;7(2):1107–1119. doi: 10.18632/oncotarget.6689

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Copyright: © 2016 Verrill et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

The expression profiles of the three significantly altered EMT-related proteins in human pT3 prostate cancers were studied in an in vivo Pten^−/− model of invasive prostate cancer. Two of the EMT-related proteins that were altered in human samples (increased cytoplasmic alpha smooth muscle actin and E-cadherin) showed similar changes in expression in prostate cancer cells in the Pten^−/− model compared with benign prostate epithelial cells in Pten^+/+ mice (adjusted-p < 0.05).