Table 2. Analysis of Gleason grades of separate prostate cancer foci within a “heterogeneity” prostate cancer tissue microarray.
| TMA Case | EPE focus of pT3a tumour | Main pT3a tumour | Separate pT2 focus of tumour |
|---|---|---|---|
| 1 | 3+4 | 3+3 | 3+3 |
| 2 | 3+4 | 3+4 | 3+4 |
| 3 | 4+3 | 4+3 | 3+4 |
| 4 | 3+4 | 3+4 | 3+3 |
| 5 | Absent | 3+4 | 3+4 |
| 6 | 4+3 | 4+3 | 3+3 |
| 7 | 4+3 | 4+3 | 3+4 |
| 8 | 4+4 | 4+4 | 3+4 |
| 9 | 3+4 | 3+4 | 4+3 |
| 10 | 3+4 | 3+4 | 3+4 |
| 11 | 3+4 | 4+3 | 3+3 |
| 12 | 3+4 | 3+4 | 3+3 |
| 13 | 4+3 | 3+4 | 3+4 |
| Gleason score 3+3=6 | |
| Gleason score 3+4=7 | |
| Gleason score 4+3=7 | |
| Gleason score 4+4=8 |
| Gleason sum score comparisons | p-value |
|---|---|
| pT3a EPE versus separate pT2 focus | 0.005 |
| pT3 main focus versus separate pT2 focus | 0.019 |
| pT3a EPE versus main pT3 focus | 0.69 |
The “heterogeneity” tissue microarray comprises samples from 13 patients and includes tissue cores from the extraprostatic extension focus, “mid-portion”, and “deep” focus of pT3a prostate cancer, a separate pT2 focus, and from various histologically benign regions of the prostate. The Gleason scores of the extraprostatic extension component of the pT3a samples in the “heterogeneity” tissue microarray were significantly different from those of the separate pT2 foci.