Figure 1. Heparanase expression is high in primary myeloma tumor cells that survive and grow following chemotherapy.

(A) Heparanase expression in purified tumor cells from nine individual myeloma patients (designated P01-P09) at specific times during the course of therapy (baseline, post-induction, post-1st transplant, post-2nd transplant) as determined by gene expression profiling (please refer to Materials and Methods for details). (B) Average expression of heparanase from nine myeloma patients after sequential rounds of chemotherapy. *p < 0.05 versus baseline.