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. 2015 Dec 7;7(2):1863–1877. doi: 10.18632/oncotarget.6495

Figure 6. Selinexor binds to XPO1 in a dose-dependent manner in Rev-GFP U2OS cells in the XPO1 occupancy assay.

Figure 6

A. Digital western blot images for eluates and inputs from Rev-GFP U2OS cells that were treated with serially increasing concentrations of selinexor and processed for the XPO1 occupancy assay. B. Plot of the ratio of free-fraction XPO1 for each selinexor concentration which was calculated by dividing the mean peak areas of XPO1 occupied by b-LMB (from the eluate) by the total amount of XPO1 (from the input), normalized to the corresponding selinexor-free control.