Table 2. b-LMB has anti-cancer activity that is less potent than unmodified LMB in a cellular cytotoxicity assay.
| Cell Line | Selinexor IC50 (nM) | LMB IC50 (nM) | b-LMB IC50 (nM) |
|---|---|---|---|
| MM.1S | 20 | 0.46 | 3.1 |
| HCT-116 | 50 | 0.19 | 6.0 |
| AML2 | 90 | 0.39 | 2.53 |
| AML3 | 270 | 0.68 | 4.68 |
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