Table 1. Pathways of the Reactome database that were highly enriched after network enrichment analysis (NEA) of the whole list of 286 Wig-1 bound targets and relative network enrichment p-value.
| Pathway | Network enrichment p-value | |
|---|---|---|
| 1 | Cell Cycle Mitotic | 0.00E+00 |
| 2 | Mitotic M-M/G1 Phases | 0.00E+00 |
| 3 | Mitotic Prometaphase | 1.39E-80 |
| 4 | G1/S Transition | 2.30E-63 |
| 5 | S Phase | 4.00E-63 |
| 6 | HIV Infection | 8.04E-63 |
| 7 | Cell Cycle Checkpoints | 4.08E-60 |
| 8 | Host Interactions Of HIV Factors | 1.06E-53 |
| 9 | Synthesis Of DNA | 1.17E-51 |
| 10 | Metabolism Of RNA | 2.83E-48 |
| 11 | Regulation Of APC Activators Between G1/S And Early | 5.29E-48 |
| 12 | NEP/NS2 Interacts With The Cellular Export Machinery | 3.67E-45 |
| 13 | Rev Mediated Nuclear Export Of HIV1 RNA | 1.65E-44 |
| 14 | Transport Of Mature mRNA Derived From An Intron Containing | 2.51E-43 |
| 15 | Transport Of Ribonucleoproteins Into The Host Nucleus | 2.95E-43 |
| 16 | Transport Of The SLBP Independent Mature mRNA | 3.46E-43 |
| 17 | Nuclear Import Of REV Protein | 7.60E-43 |
| 18 | Late Phase Of HIV Life Cycle | 2.26E-41 |
| 19 | Dna Replication Pre Initiation | 2.03E-40 |
| 20 | HIV Life Cycle | 2.24E-40 |