Figure 2. A new statistical framework was developed to identify a robust multimarker signature for accurate outcome prediction.

The framework consists of three major steps: (1) signatures construction, (2) evaluation of the performance and robustness of the constructed signatures and (3) the selection of the final signature. Details of every step are described in the Materials and Methods section. a: assay; s: sample; TPR: true positive rate (sensitivity); TNR: true negative rate (specificity); balanced accuracy (BAC).