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. 2015 Dec 9;7(2):1973–1983. doi: 10.18632/oncotarget.6538

Figure 3. Alternative NAPRT transcripts predicted in Ensembl Genome Browser.

Figure 3

Alignment of the predicted NAPRT transcripts from Ensembl, showing the differences to the reference sequence. The transcript NAPRT-002 corresponds to the reference sequence (NM_145201.5). Transcripts NAPRT-003 and -004 are protein coding. NAPRT1-003 has a deletion of 39 base pairs corresponding to 13 amino acids in exon 11, while the remaining sequence is maintained. NAPRT1-004 retains part of intron 11 resulting in a premature STOP codon. Transcripts NAPRT-001 and -010, classified as nonstop mediated decay, retain intron 12 and the consequent alteration of the reading frame leads to the readthrough of the STOP codon. Transcripts NAPRT-013 and -014, classified as nonsense mediated decay, lack exon 5, yet their sequence is incomplete. The remaining transcripts have several retained introns and no complete sequence is described.