Figure 3.

Kaplan-Meier graphs depicting OS in months of (A). patients in which liver metastases were not treated with systemic therapy, (B) patients in which liver metastases were treated with systemic therapy, (C) colon cancer patients, and (D) rectal cancer patients, stratified by the classes as identified using the Classification and Regression Trees (CART) analysis. Excluded from analysis were patients with unknown or less than two months survival, unknown systemic therapy or primary tumor localization and with unknown expression of AURKA, PTGS2 and MMP9. The p-value is the corrected p-value as determined by permutation analysis.