Table 2. Univariate and multivariate average hazard rate ratios of the investigated candidate biomarkers.

	univariate			multivariate
Biomarker	HRRav	P (HRR < 1)	P (HRR > 1)	HRRav	P (HRR < 1)	P (HRR > 1)
EGFR [31]	1.47	.03*		1.54	.02*
PI3K	0.88		.20	0.80		.20
AURKA [32]	1.57	.02*		1.66	.02*
Ki-67	1.15	.21		1.17	.20
TK1	1.22	.26		1.31	.23
KCNQ1	0.81		.09	0.81		.09
IGF2	0.97		.39	0.96		.37
VEGFA [33]	1.48	.02*		1.50	.02*
PDGFR β	1.13	.29		1.10	.35
CEA	0.68		.06	0.63		.05
MMP9	1.29	.08		1.34	.07
CXCR4	0.94		.33	0.91		.25
CXCL12	0.90		.23	0.93		.31
MLH1	1.16	.23		1.17	.21
MSH6	0.81		.11	0.82		.13
PTGS2 [31]	1.63	< .01*		1.59	.01*
SLC2A1 [33]	0.67		< .01*	0.65		< .01*
HIF1α [33]	0.80		.06	0.77		.06

HRR_av: average hazard rate ratio; P (HRR < 1): proportion of HRRs with HRR < 1; P (HRR > 1): proportion of HRRs with HRR > 1

^*P (HRR < 1) or P(HRR > 1) < .05