Table 2. Summary of somatic SNVs and small indels.

Category	P1-1 b	P1-2	P2-1	P2-2	P2-3	P3-1	P3-2	P3-3	L1	L2
A:SNV
downstream	31	46	47	49	45	31	36	31	30	33
intergenic	1258	4046	1334	2054	1314	973	2181	1648	922	4169
intronic	1728	2137	2217	2932	2483	1592	1656	1562	1656	1701
Within_non_coding_gene	596	725	606	674	622	502	533	480	489	543
upstream	28	51	32	54	41	38	35	24	53	55
upstream;downstream	24	38	22	20	25	19	24	18	18	24
UTR3	522	579	632	740	678	559	571	555	594	590
UTR5	104	128	116	125	122	125	124	123	129	124
stop_gaineda	7	7	5	4	5	4	5	6	4	8
nonsynonymous_CODINGa	262	271	238	244	241	257	265	250	258	264
synonymous_CODING	308	316	284	292	287	285	288	282	286	291
splicinga	4	4	2	2	2	4	4	4	5	5
B:indel
downstream	6	11	9	12	9	10	10	9	7	8
intergenic	58	177	107	124	101	69	100	72	62	135
intronic	226	530	532	632	541	366	391	341	305	316
Within_non_coding_gene	32	60	56	64	60	52	53	45	52	63
upstream	3	10	6	10	6	5	7	4	6	8
UTR3	107	248	240	263	236	216	240	209	193	203
UTR5	11	28	26	31	31	28	29	26	31	31
frameshift_codinga	10	11	12	13	13	14	13	12	12	11
nonframeshift_codinga	4	4	4	4	4	3	3	3	3	3
splicinga			1	1	1	1	1	1	1	1

^a Mutations from these categories might alter protein.

^b P1-1 and P1-2 are primary-tumor regions of colectomy specimen from patient 1; P2-1~P2-3 are primary-tumor regions of colectomy specimen from patient 2; P3-1~P3-3 are primary-tumor regions of colectomy specimen from patient 3, L1 and L2 are two regions of the excised liver metastasis lesion from patient 3.