Table 5.
Anchors in other BCR and TCR genes. The default amino acid at position 98 is D. The default amino acids at position 102–104 are YYC. Leucine (L) and Phenylalanine (F) are very common variants at position 103.
| D at 98 | YYC at 102–104 | ||||||
|---|---|---|---|---|---|---|---|
| Number of alleles |
V gene type |
Total No. of germline genes |
With NT variation |
With AA variation |
With NT variation |
With AA variation (YLC/YFC) |
With AA change at both positions |
| Human | □ | 49 | 2 | 1 | 6 | 5 | 0 |
| κ | 61 | 0 | 0 | 29 | 2 | 0 | |
| λ | 65 | 20 | 0 | 31 | 4 | 0 | |
| α | 88 | 25 | 3 | 0 | 78 (24/48) | 0 | |
| β | 106 | 34 | 28 | 0 | 106 (51/41) | 0 | |
| Mouse | Heavy | 258 | 22 | 3 | 99 | 50 | 1 |
| κ | 120 | 20 | 0 | 74 | 31 | 0 | |
| α | 206 | 40 | 0 | 0 | 165 (36/124) | 0 | |
| β | 46 | 17 | 16 | 0 | 46 (19/21) | 0 | |