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ExoT is sufficient to cause cytotoxicity in cancer cells in vitro. Indicated cancer cells were transfected with pGFP vector control or pExoT-GFP and cytotoxicity was assessed by time-lapse fluorescence video microscopy in the presence of PI. (a) Tabulated data for A375, MCF-7, EMT6 and Calu-3. (b) Representative frames of B16 transfected with pExoT-GFP or pGFP. (c) Tabulated data for B16. *P<0.0001; n = 3 independent experiments each with ~100 events counted; Student’s t-test.
