Fig. 5.

ExoT slows B16 tumour burden in vivo. (a) B16 tumour cells were transfected with pGFP or pExoT ex vivo. At 15 h after transfection, 1×10⁵ pGFP- or pExoT-GFP-transfected B16 tumour cells were transferred subcutaneously by injection in the flank of C57BL/6 mice. Tumour size was measured daily by use of callipers until tumours reached 150 mm². Tumour sizes are shown as mean±sem from the time of injection to the first animal death. n = 5 mice per group, *P<0.05. (b) Individual tumour growth curves for the experiment performed in (a).