Skip to main content
. Author manuscript; available in PMC: 2016 Aug 19.
Published in final edited form as: Mod Pathol. 2016 Feb 19;29(4):359–369. doi: 10.1038/modpathol.2016.37

Figure 4. Complex genomic rearrangements involving ALK, TPM3, and IL6R.

Figure 4

Spitzoid melanocytic neoplasm in the calf of a 13-year-old female (patient 4). (A) H&E photomicrograph showing nests of spindled melanocytes with ulceration. (B) ALK immunoreactivity highlights a fascicular architecture in the dermis. (C, D) Break-apart FISH for ALK and IL6R confirms rearrangements in the respective genes. (E–H) Schematic of the TPM3–ALK fusion gene. The first 222 amino acids of TPM3 are fused to the C terminus of ALK, incorporating the intact tyrosine kinase domain of ALK. The remaining TPM3 protein is fused to the IL6R protein. The identification of multiple fusions involving TPM3 suggests a complex translocation event.