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. Author manuscript; available in PMC: 2017 May 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Dec 29;299:78–89. doi: 10.1016/j.taap.2015.12.022

Figure 3.

Figure 3

Structure–activity relationship summary. Shown are the structure–activity relationships between nanoparticles and their effects on the immune system. Each block listed in the bottom (structure) part of the figure is color-coded. To find what toxicity is related to the given structure block, please find the block in the top (activity) part of the figure marked with the color matching that of the structure block. PCA – Procoagulant activity, DIC – Disseminated intravascular coagulation, CARPA – Complement activation-related pseudoallergy, MPS – Mononuclear phagocytic system, IL – Interleukin, PEG – Polyethylene glycol, NP – Nanoparticle, DXR – Doxorubicin, API – Active pharmaceutical ingredient, DNA – Deoxyribonucleic acid.