Table 1.
Factors potentially association with remission of intermediate uveitis*
| Characteristics | Characteristic Value | Total Eyes | Remissions Observed | Eye-Years | Incidence rate (95% CI) | Crude HR of Remission (95% CI) | Adjusted HR of Remission |
|---|---|---|---|---|---|---|---|
| Number of eyes | 849 | 167 | 1934.4 | .086 (.074 – .10) | |||
| Age | Age<18 | 154 | 34 | 419.31 | .081 (.056 – .11) | 1.18(0.68 – 2.04) | 0.95(0.53 – 1.70) |
| 18≤Age<30 | 211 | 35 | 550.85 | .064 (.044 – .088) | 0.96(0.54 – 1.68) | 0.82(0.46 – 1.46) | |
| 30≤Age<45 | 271 | 43 | 596.42 | .0721 (.052 – .097) | Reference group | Reference group | |
| Age≥45 | 213 | 55 | 367.79 | .15 (.11– .19) | 2.00(1.21 – 3.30) | 1.79(1.03 – 3.11) | |
| Gender | Male | 315 | 44 | 790.67 | .056 (.040 – .075) | 1.00 | 1.00 |
| Female | 534 | 123 | 1143.7 | .11 (.089 – .13) | 1.82(1.18 – 2.81) | 1.61(1.04 – 2.49) | |
| Race | White | 731 | 151 | 1665.0 | .0907 (.077 – .11) | Reference group | Reference group |
| Black | 43 | 5 | 138.59 | .036 (.012 – .084) | 0.46(0.13 – 1.61) | 0.53(0.14 – 2.04) | |
| Hispanic | 34 | 9 | 31.14 | .29 (.13 – .55) | 2.39(0.96 – 5.95) | 2.81(1.23 – 6.41) | |
| Other | 41 | 2 | 99.64 | .020 (.0024 – .073) | 0.24(0.05 – 1.07) | 0.26(0.06 – 1.19) | |
| Any systemic disease** | Yes | 94 | 14 | 266.60 | .053 (.029 – .088) | 0.62(0.30 – 1.24) | 0.59(0.29 – 1.22) |
| Juvenile idiopathic arthritis | Yes | 8 | 5 | 29.61 | .17 (.055 – .39) | 2.25(0.70 – 7.22) | 1.50(0.39 – 5.83) |
| Sarcoidosis | Yes | 43 | 9 | 116.21 | .077 (.035 – .15) | 0.94(0.40 – 2.21) | 0.63(0.23 – 1.70) |
| Multiple sclerosis | Yes | 40 | 7 | 84.50 | .083 (.033 – .17) | 0.89(0.42 – 1.90) | 0.73(0.30 – 1.73) |
| Smoking status | Never Smoker | 425 | 97 | 1001.6 | .097 (.079 – .12) | Reference group | Reference group |
| Former Smoker | 70 | 24 | 176.14 | .14 (.087 – .20) | 1.37(0.79 – 2.40) | 0.97(0.54 – 1.76) | |
| Current Smoker | 216 | 32 | 443.45 | .072 (.049 – .10) | 0.71(0.43 – 1.16) | 0.79(0.46 – 1.35) | |
| Unknown | 138 | 14 | 313.19 | .045 (.024 – .075) | 0.43(0.21 – 0.87) | 0.41(0.20 – 0.86) | |
| Number of years since diagnosis of uveitis | ≤ 1 year | 415 | 42 | 137.45 | .31(.22 – .41) | 3.81(1.94 – 7.48) | 3.82(1.91 – 7.63) |
| >1 to 5 years | 264 | 70 | 715.55 | .098 (.076 – .12) | 1.55(0.91 – 2.65) | 1.50(0.87 – 2.60) | |
| over 5 years | 170 | 55 | 1081.4 | .051 (.038 – .066) | Reference group | Reference group | |
| Bilateral uveitis | Yes | 771 | 150 | 1774.7 | .085 (.072 – .099) | 0.82(0.48 – 1.39) | 0.73(0.43 – 1.23) |
| Snowballs at enrollment | Yes | 234 | 40 | 427.89 | .094 (.067 – .13) | 1.04(0.69 – 1.56) | 0.98(0.66 – 1.46) |
| Peripheral ablation*** | Yes | 44 | 9 | 83.23 | .11 (.049 – .21) | 1.31(0.67 – 2.55) | 1.71(0.84 – 3.45) |
| Pars plana vitrectomy | Yes | 81 | 23 | 123.64 | .19 (.12 – .28) | 2.84(1.76 – 4.58) | 2.39(1.42 – 4.00) |
CI=confidence interval; HR=hazard ratio; adjusted values are adjusted for age, sex, race, smoking status, presence of snowballs at the initial visit, the number of years since uveitis diagnosis, and whether or not peripheral ablation or pars plana vitrectomy were performed.
There were no cases of reactive arthritis, psoriatic arthritis, polyarteritis nodosum, Wegener’s, Takayasu, scleroderma, Sjogren’s, dermatomyositis, polymyositis, relapsing polychrondritis, Cogan’s, or familial systemic granulomatosis. There was no association observed between intermediate uveitis remission and spondylarthropathy (i.e. ankylosing spondylitis), Behcet Disease, systemic lupus erythematosis, rheumatoid arthritis, Crohn’s disease, ulcerative colitis, HLA-B27+ status, or HLA-A29+ status; however available power often was limited to detect such associations if they in fact exist.
Peripheral retina/pars plana ablation using either cryotherapy or scatter photocoagulation.