Table 5.
Per-patient and per-episode glycemic control results for the STAR and SPRINT cohorts in Christchurch and Gyula Hospital ICU
| SPRINT Chch | STAR Chch | STAR Gyula | P value | ||
|---|---|---|---|---|---|
| SPRINT Chch, STAR Chch | STAR Gyula, STAR Chch | ||||
| Number patients | 292 | 267 | 47 | – | – |
| Number episodes | 355 | 336 | 47 | – | – |
| Glycemic performance—per-patient raw data | |||||
| Median [IQR] BG mean | 5.9 [5.5–6.3] | 7.0 [6.6–7.6] | 6.9 [6.6–7.4] | <0.05 | 0.60 |
| Median [IQR] BG SD | 1.2 [1.0–1.6] | 1.5 [1.2–2.1] | 1.6 [1.3–1.9] | <0.05 | 0.50 |
| Median [IQR] BG median | 5.7 [5.3–6.1] | 6.7 [6.3–7.3] | 6.6 [6.3–7.1] | <0.05 | 0.28 |
| # (%) Patients <4.0 mmol/l | 181 (62.0 %) | 70 (26.3 %) | 25 (53.2 %) | <0.05 | <0.05 |
| # (%) Patients <2.22 mmol/l | 1 (0.3 %) | 4 (1.5 %) | 2 (4.3 %) | 0.20 | 0.22 |
| Glycemic performance—per-episode hourly interpolated | |||||
| Median [IQR] BG mean | 5.8 [5.4–6.2] | 6.7 [6.4–7.3] | 6.7 [6.5–7.1] | <0.05 | 0.60 |
| Median [IQR] BG SD | 1.1 [0.8–1.5] | 1.2 [0.9–1.7] | 1.3 [1.04–1.5] | <0.05 | 0.23 |
| Median [IQR] BG median | 5.6 [5.2–6.0] | 6.5 [6.2–7.0] | 6.5 [6.3–6.7] | <0.05 | 0.61 |
| % time >10.0 mmol/l | 0.0 [0.0–1.6] | 1.6 [0.0–6.5] | 2.4 [0.7–5.4] | <0.05 | 0.16 |
| % time 4–6.1 mmol/l (SPRINT target) | 65.6 [52.4–77.9] | 29.8 [12.4–45.9] | 33.3 [21.5–40.9] | <0.05 | 0.49 |
| % time 4.4–8.0 mmol/l (STAR target) | 93.0 [85.0––97.5] | 86.6 [75.0–94.1] | 87.1 [79.3–91.1] | <0.05 | 0.81 |
| % time <4.4 mmol/l | 7.3 [2.1–16.1] | 0.0 [0.0–1.8] | 0.9 [0.0–2.8] | <0.05 | <0.05 |
| % time <4.0 mmol/l | 1.4 [0.0–5.71] | 0.0 [0.0–0.0] | 0.0 [0.0–1.8] | <0.05 | <0.05 |
| % time <2.22 mmol/l | 0.0 [0.0–0.0] | 0.0 [0.0–0.0] | 0.0 [0.0–0.0] | 0.97 | 0.71 |
| Intervention performance—per episode (excluding not fed) | |||||
| Median [IQR] mean insulin (U/h) | 2.2 [0.0–2.8] | 2.7 [1.9–3.5] | 3.2 [2.4–4.6] | <0.05 | <0.05 |
| Total hours not fed (%) | 16430 (40.1 %) | 2305 (10.0 %) | 0 (0.0 %) | – | – |
| Median [IQR] mean goal feed (%) | 73 [52–86] | 86 [64–97] | 80 [74–88] | <0.05 | 0.28 |
| Median[IQR] mean total glucose(g/h) | 4.2 [3.1–5.4] | 5.1 [4.0–6.2] | 7.4 [6.2–8.9] | <0.05 | <0.05 |
| Median [IQR] mean enteral glucose (g/h) | 4.1 [3.0–5.3] | 4.5 [2.6–5.6] | 3.04 [1.48–5.40] | 0.74 | <0.05 |
| Median [IQR] mean parenteral glucose (g/h) | 0.0 [0.0–0.0] | 0.0 [0.0–1.1] | 4.05 [2.84–5.69] | <0.05 | <0.05 |
Data are presented as median [inter-quartile range (IQR)] where appropriate