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. 2016 Mar 30;7:367. doi: 10.3389/fmicb.2016.00367

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Copyright © 2016 Linhares-Lacerda and Morrot.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MicroRNA modulation during parasitic infection: clues from Gene Ontology (GO) enrichment analysis of microRNA in silico-predict targets. (A) Mice with acute Trypanosoma cruzi infection modulate microRNA expression in thymic epithelial cells, with some microRNAs upregulated (red) and others undetectable (gray). The regulated microRNAs were used to identify biological processes (depicted within the square) that were over-represented among the list of microRNA target genes. (B) The examination of mature microRNA expression patterns in human macrophages revealed unique microRNA profiles in response to the Leishmania major and L. donovani parasites. In addition, biological pathway enrichment was performed for the dysregulated microRNAs to identify signaling pathways (depicted within the square) that might be involved.