Figure 6.

Post-CCI mdivi-1 treatment rescues contextual memory after CCI injury. CCI animals were treated with either 3.0 mg/kg of Mdivi-1 (n = 8) or vehicle (n = 6) starting 30 min post-injury, and subsequently at 24 and 48 h post-injury. Four weeks post-injury, rats were exposed to the FC training chamber, before receiving a mild foot shock (2 s, 7.0 mV). Prior to foot shock, animal in all three groups explored the context equally (training). Twenty-four hours later (one-trial) the rats were replaced back into the training chamber and their freezing behavior was recorded for a total of 3 min. Rats treated with Mdivi-1 demonstrated improved contextual fear memory in a one-trial context-specific FC task indicated by a significant increase in freezing behavior compared to vehicle-treated controls. Data are presented as the mean ± SEM. *p < 0.05.