Table 1.
Characterization of K+ channels associated to obesity.
| Localization | Species | K+ channel subtype (gene) | Comments | Reference |
|---|---|---|---|---|
| Subcutaneous preadipocytes | Human | KV1.1 (KCNA1) KV1.5 (KCNA5) KV2.1 (KCNB1) KV7.1 (KCNQ1) KV10.1 (KCNH1) KV11.1 (KCNH2) KCa1.1 (KCNMA1) KV4.2 (KCND2) | Promote preadipocytes proliferation | Bai et al., 2007; Hu et al., 2009 |
| Brown adipocytes | Rat | KV (?) | Associated with adipose cells proliferation | Pappone and Ortiz-Miranda, 1993 |
| Central nervous system | Mice | Kir6.2 (Kcnj11) | Mediates the glucose-sensitive neuronal excitation and regulates food intake | Miki et al., 2001; Sohn, 2013 |
| K2P/KV3 [Kcnk1–7, 9, 10, 12, 13, 15–17; Kcck18 (?)] | Activated by high glucose levels and inhibits orexin/hypocretin release | Burdakov et al., 2006 | ||
| KV1.3 (KCNA3) | Regulation of energy homeostasis, body weight, and insulin resistance | Xu et al., 2003, 2004 | ||
| Rat | KV3.1 (Kcnc1) | Regulates response of taste cells to fat ingestion and the leaning to high fat intake | Gilbertson et al., 2005 |