Table 2.
Characterization of TRPs associated to obesity.
| Localization | Species | TRP channel (gene) | Comments | Reference |
|---|---|---|---|---|
| Adipocytes | Mice | TRPC1 (Trpc1) TRPC5 (Trpc5) | Channels related to the adiponectin production | Sukumar et al., 2012 |
| TRPM8 (Trpm8) | Menthol, a TRPM8 agonist, increases the expression of UCP1 and the level of p-PKA | Ma et al., 2012 | ||
| 3T3-LI- preadipocytes | Mice | TRPV1 (Trpv1) | Adipogenesis process is decreased | Zhang et al., 2007 |
| BAT | Mice | TRPM8 (Trpm8) | Stimulation of this channel mediates BAT thermogenesis | Ma et al., 2012 |
| TRPA1 (Trpa1) | Cinnamaldehyde, a TRPA1 agonist, increases the UCP1 protein levels | Tamura et al., 2012 | ||
| WAT | Mice | TRPV4 (Trpv4) | Regulator of oxidative metabolism, thermogenesis, and pro-inflammation gene | Ye et al., 2012 |
| TRPM2 (Trpm2) | Regulates of lipid metabolism | Zhang et al., 2012 | ||
| Perivascular adipose tissue | Human | TRPC1 (TRPC1) TRPC5 (TRPC5) | Channels are related to the adiponectin production | Sukumar et al., 2012 |
| Visceral and subcutaneous adipose tissues | Human | TRPV1 (TRPV1) | Adipogenesis process is decreased | Zhang et al., 2007 |
| Mice | TRPA1 (Trpa1) | Cinnamaldehyde, a TRPA1 agonist, reduces the visceral fat in both mice fed with a high-fat and high-sucrose | Tamura et al., 2012 | |
| TRCs | Mice | TRPM5 (Trpm5) | Disruption on the channel abolishes the sweet, umami, and bitter tastes | Zhang et al., 2003 |
| EC cells | Rat | TRPA1 (Trpa1) | Allyl isothiocyanate and cinnamaldehyde, TRPA1 agonists, increase [Ca2+]i, 5-HT release and delay gastric emptying | Doihara et al., 2009; Nozawa et al., 2009 |
| Whole body fat | Human | TRPV1 (TRPV1) | SNP Val585IIe is associated to weight loss | Hayes et al., 2000 |
| Mice | TRPM5 (Trpm5) | TRPM5(-/-) mice present a loss on sucrose preference and gain less weight that WT mice | Glendinning et al., 2012 | |
| TRPV1 (Trpv1) | TRPV1(-/-) mice present equivalent energy intake that WT mice | Motter and Ahern, 2008 |