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E17.5 first molars cultured with MetBIO or BIO (20 μM) for 48 h. In situ hybridization for Lef1 (A,B), Dkk1 (C,D), Bmp4 (E,F), Wnt10b (G,H), Shh (I,J) and Epfn (K,L). Sections of cultured molars showing that Wnt/β-catenin overactivation increased gene expression in dental epithelium (Lef1 and Epfn, B,L) and/or dental mesenchyme (Dkk1, Bmp4, and Epfn); however, Wnt10b and Shh (H,J) expression was reduced with BIO treatment. Scale bars: 200 μm.
