Table 4.
Correlations between the CNS structures and the neuropsychological test results across the entire sample.
| Structure | RAVLT items 1-5 sum (n = 62) Pearson r (p-value*) | ACEa Total Score (n = 61) Pearson r (p-value*) | Trail Making Test part B (n = 60) Pearson r (p-value*) | Stages Completed in the PALb test (n = 49) Spearman r (p-value*) |
|---|---|---|---|---|
| CORTICAL THICKNESS (IN mm) | ||||
| Entorhinal cortex | 0.60 (p ≤ 0.001) | 0.58 (p ≤ 0.001) | 0.20 (p = 0.129) | 0.47 (p ≤ 0.001) |
| Fusiform gyrus | 0.52 (p ≤ 0.001) | 0.53 (p ≤ 0.001) | 0.29 (p = 0.026) | 0.37 (p = 0.008) |
| Isthmus of cingulate gyrus | 0.40 (p = 0.001) | 0.37 (p = 0.004) | 0.34 (p = 0.008) | 0.23 (p = 0.109) |
| Parahippocampal gyrus | 0.32 (p = 0.010) | 0.28 (p = 0.027) | 0.14 (p = 0.269) | 0.24 (p = 0.098) |
| Posterior cingulate | 0.30 (p = 0.020) | 0.32 (p = 0.012) | 0.24 (p = 0.070) | 0.24 (p = 0.100) |
| Precuneus | 0.48 (p ≤ 0.001) | 0.44 (p ≤ 0.001) | 0.40 (p = 0.001) | 0.35 (p = 0.013) |
| VOLUMES (IN mm3) | ||||
| Entorhinal cortex | 0.31 (p = 0.013) | 0.36 (p = 0.004) | 0.12 (p = 0.342) | 0.19 (p = 0.194) |
| Fusiform gyrus | 0.28 (p = 0.030) | 0.37 (p = 0.004) | 0.29 (p = 0.027) | 0.34 (p = 0.015) |
| Isthmus of cingulate | 0.01 (p = 0.955) | 0.04 (p = 0.752) | 0.16 (p = 0.234) | 0.09 (p = 0.543) |
| Parahippocampal gyrus | 0.22 (p = 0.082) | 0.25 (p = 0.053) | 0.01 (p = 0.959) | 0.14 (p = 0.353) |
| Posterior cingulate | 0.13 (p = 0.308) | 0.18 (p = 0.168) | 0.30 (p = 0.020) | 0.19 (p = 0.182) |
| Precuneus | 0.02 (p = 0.890) | 0.07 (p = 0.583) | 0.24 (p = 0.065) | 0.14 (p = 0.320) |
| Hippocampus | 0.50 (p ≤ 0.001) | 0.51 (p ≤ 0.001) | 0.15 (p = 0.238) | 0.43 (p = 0.002) |
| Amygdala | 0.40 (p = 0.001) | 0.45 (p ≤ 0.001) | 0.06 (p = 0.623) | 0.51 (p ≤ 0.001) |
a
ACE = Addenbrooke's cognitive examination (maximum score is 100).
b
PAL test = Paired Associates Learning test.
*
Significant between group differences after correction for multiple comparisons (p < 0.0125) are bolded. Level of significance was set to 0.05/4 = 0.0125, where four stands for the number of the neuropsychological tests analyzed.