Table 2.
Regional differences in GM volume between patients with ALS and HCs.
| Region | Maximum | Clusters | Jackknife sensitivity analysis | |||
|---|---|---|---|---|---|---|
| MNI coordinate (x,y,z) | SDM-Z | P-values | No. of voxels | breakdown (No. of voxels) | ||
| Left rolandic operculum, BA 48 | −50, 4, 2 | −4.027 | ~0 | 7067 | Left frontal gyrus (1301) | 28 out of 29 |
| Left precentral gyrus (1182) | ||||||
| Left temporalgyrus (1083) | ||||||
| Left postcentral gyrus (894) | ||||||
| Left insula (702) | ||||||
| Corpus callosum (488) | ||||||
| Left rolandic operculum (459) | ||||||
| Left paracentral lobule (258) | ||||||
| Other/Undefined (624) | ||||||
| Right precentral gyrus, BA 6 | 42, −16, 46 | −3.062 | 0.000005186 | 1544 | Right precentral gyrus (798) | 29 out of 29 |
| Right postcentral gyrus (453) | ||||||
| Other/Undefined (293) | ||||||
| Left anterior cingulate/paracingulate gyri | 0,46,4 | −2.395 | 0.000304461 | 873 | Left anterior cingulate /paracingulate gyri (394) | 28 out of 29 |
| Right anterior cingulate /paracingulate gyri (212) | ||||||
| Left superior frontal gyrus, medial (141) | ||||||
| Right superior frontal gyrus, medial (119) | ||||||
| Other/Undefined (7) | ||||||
| Right lenticular nucleus, putamen, BA 48 | 28, 16, −4 | −2.291 | 0.000449002 | 383 | Right lenticular nucleus, putamen (173) | 27 out of 29 |
| Right insula (64) | ||||||
| Right striatum (39) | ||||||
| Other/Undefined (107) | ||||||
| Right rolandic operculum, BA 48 | 52, 6, 6 | −1.843 | 0.003767371 | 43 | Right rolandic operculum (35) Other (8) |
20 out of 29 |
ALS, amyotrophic lateral sclerosis; BA, Brodmann; GM, gray matter; HC, healthy control; MNI, Montreal Neurological Institute; SDM, signed differential mapping.