Table 4.
Meta-regression analyses of disease severity and duration on GM abnormalities in patients with ALS.
| Regions | Peak MNI coordinate (x,y,z) | SDM-Z | P-values | No. of Voxels |
|---|---|---|---|---|
| DISEASE SEVERITY | ||||
| Right precentral gyrus, BA6 | 32, −14, 62 | −3.025 | 0.000030994 | 339 |
| Left inferior frontal gyrus, BA 44 | −54, −16, 16 | −2.410 | 0.001145720 | 218 |
| DISEASE DURATION | ||||
| Left frontal aslant tract | −54,4,10 | −3.216 | ~0 | 690 |
| Right precentral gyrus, BA4 | 46, −12,40 | −2.373 | 0.000165164 | 327 |
ALS, amyotrophic lateral sclerosis; BA, Brodmann; GM, gray matter; MNI, Montreal Neurological Institute; SDM, signed differential mapping.