Figure 11.

Voltage dependent Na_V current activation and inactivation in developing NM neurons. (A) Representative Na_V current traces recorded from an E20 NM neuron in response to membrane voltages clamped from −55 to −5 mV (voltage step = 5 mV, voltage duration = 100 ms). (B–D) Population data showing the relationship of peak Na_V current (peak I_Na, B), conductance (G_Na, C) and density (ρ_Na, D) to the varying membrane voltages for each age group. (E) Representative Na_V current traces recorded from an E20 NM neuron in response to depolarization to −30 mV following pre-pulse holding voltages clamped from −90 to −30 mV (voltage step = 10 mV). (F) Population data showing voltage dependence of Na_V channel inactivation for each age group. h_Na was calculated as the Na_V current recorded for each trial normalized to the maximum current across all trials and plotted as a function of the pre-pulse holding voltage. Error bars = standard error.