Table 1.

Genes identified to interact with NKX2-1/Nkx2-1 in human or rodent studies that have also been associated with susceptibility for development of schizophrenia or with the course of illness.

Gene name	Gene symbol	Species	Tissue	Process	Selected references
Adenylate cyclase activating polypeptide 1	Adacyp1a	R	Retina, hypothalmus	Circadian rhythm, synaptic plasticity	Kim et al., 2002; Hashimoto et al., 2007; Son et al., 2007
Adenomatous polyposis coli	Apcb	M	Lung	Neuroendocrine cell differentiation	Cui et al., 2005; Li C. et al., 2013
Calreticulin	CALRb	H	Thyroid, lung	Immune system regulation	Perrone et al., 1999; Aghajani et al., 2006; Takahashi et al., 2006
Cholinergic receptor, nicotinic, alpha 7	Chrna7a	M	Lung	Lung development	Leonard et al., 2002; Reynolds and Hoidal, 2005; Luo et al., 2014
Clock circadian regulator	Clockb	R	Hypothalamus	Circadian rhythm	Kim et al., 2002; Takao et al., 2007; Waddington et al., 2010; Zhang et al., 2011; Matagne et al., 2012
CREB binding protein	CREBBPc	H	Lung	Lung development and function	Naltner et al., 2000; Yi et al., 2002; Crisafulli et al., 2012
Ciliary neurotrophic factor	CTNF c	H	Forebrain	Astrocyte formation	Thome et al., 1996; Chojnacki and Weiss, 2004
Distal-less homeobox 1	Dlx1c	M	Forebrain	Ventral forebrain development	Marin et al., 2000; Kahler et al., 2008; Goulburn et al., 2011
V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	ErbB2a	R	Hypothalamus	Central regulation of puberty	Ojeda et al., 2000; Benzel et al., 2007
V-erb-b4 avian erythroblastic leukemia viral oncogene homolog 4	ErbB4a	M	Forebrain, hypothalamus, lung	Interneuron migration and maturation, central regulation of puberty, lung cell development	Benzel et al., 2007; Zscheppang et al., 2013
Forkhead box P2	FOXP2b	M	Forebrain, lung	Emotional responses, surfactant production	Sanjuan et al., 2006; Zhou et al., 2008; Carney et al., 2010; Li T. et al., 2013
Paired box 6	PAX6c	H	Forebrain	Dorso-ventral brain patterning	Stober et al., 1999; Stoykova et al., 2000
Paired-like homeobox 2b	PHOX2Bc	H	Forebrain, enteric ganglia	Oligodendrocyte development, enteric nervous system development, gut function	Ide et al., 2005; Leon et al., 2009
Proenkephalin	Penka	R	Hypothalamus	Central regulation of puberty	Mikesell et al., 1996; Ojeda et al., 2000
Retinoic acid receptor, alpha	Rarac	M	Lung	Protein-protein interactions to enhance transcription	Yang et al., 2004; Rioux and Arnold, 2005
Ret proto-oncogene	RETc	H	Enteric ganglia	Enteric nervous system development, gut function	Leon et al., 2009; Glessner et al., 2010
SRY (sex determining region Y)-box 10	SOX10c	H	Brain, enteric ganglia	Oligodendrocyte development, gut function	Maeno et al., 2007a; Leon et al., 2009; Yuan et al., 2013
Sp1 transcription factor	SP1b	H	Lung	Lung development, host defense	Li et al., 2000; Pinacho et al., 2013
Sp3 transcription factor	SP3b	H	Lung	Lung development, host defense	Li et al., 2000; Pinacho et al., 2013
Sp8 transcription factor	Sp8c	M	Forebrain	Dorsoventral patterning, interneuron formation	Zembrzycki et al., 2007; Kondo et al., 2013
Transcription factor 4	Tcf4c	M	Forebrain	Formation of cortical GABAergic interneurons	Tebar et al., 2001; Lennertz et al., 2011; Wang H. et al., 2011; Quednow et al., 2012
Transforming growth factor, beta 1	Tgfb1b	M	Lung	Inflammation	Li et al., 2002; Frydecka et al., 2013
Tumor necrosis factor	Tnfb	M	Lung	Inflammation	Das et al., 2011; Paul-Samojedny et al., 2013

^a Downstream target;

^b Upstream regulator;

^cOther interaction.

M, Mouse; R, Rat; H, Human.