Table 1.
Associations of CSF3 SNP rs8078723 in the human cohort.
| Overall (N = 1,859) | |||||
| TT | TC | CC | padd | pdom | |
| N (women/men) | 758 (484/274) | 870 (586/284) | 231 (161/70) | – | – |
| AUC glucose (mmol/L) | 14.4 ± 0.1 | 14.9 ± 0.1 | 14.7 ± 0.2 | 0.0139 | 0.0007 |
| ISI-OGTT (1019 L2/mol2) | 13.8 ± 0.2 | 13.2 ± 0.2 | 13.6 ± 0.5 | 0.1 | 0.0295 |
| IRI-AT (10−18 mol2/L2) | 34,085 ± 817 | 37,464 ± 902 | 37,460 ± 1575 | 0.0231 | 0.0126 |
| Leukocytes (μL−1) | 6,478 ± 115 | 6,640 ± 61 | 6,714 ± 118 | 0.0066 | 0.0029 |
| Low FFAs (N = 743) | |||||
| TT | TC | CC | padd | pdom | |
| N (women/men) | 321 (163/158) | 335 (181/154) | 87 (54/33) | – | – |
| AUC glucose (mmol/L) | 13.9 ± 0.1 | 14.2 ± 0.1 | 13.8 ± 0.3 | 0.5 | 0.2 |
| ISI-OGTT (1019 L2/mol2) | 14.4 ± 0.4 | 14.0 ± 0.4 | 13.6 ± 0.7 | 0.1 | 0.1 |
| IRI-AT (10−18 mol2/L2) | 23,064 ± 723 | 24,123 ± 708 | 25,988 ± 1715 | 0.1 | 0.2 |
| Leukocytes (μL−1) | 6,627 ± 248 | 6,535 ± 99 | 6,875 ± 225 | 0.2 | 0.4 |
| High FFAs (N = 742) | |||||
| TT | TC | CC | padd | pdom | |
| N (women/men) | 269 (206/63) | 372 (291/81) | 101 (78/23) | – | – |
| AUC glucose (mmol/L) | 15.1 ± 0.2 | 15.7 ± 0.1 | 15.1 ± 0.3 | 0.2 | 0.0113 |
| ISI-OGTT (1019 L2/mol2) | 14.0 ± 0.5 | 12.2 ± 0.3 | 13.8 ± 0.8 | 0.2 | 0.0117 |
| IRI-AT (10−18 mol2/L2) | 45,755 ± 1664 | 51,280 ± 1660 | 48,834 ± 2633 | 0.06 | 0.0215 |
| Leukocytes (μL−1) | 6,313 ± 104 | 6,799 ± 95 | 6,630 ± 159 | 0.0038 | 0.0002 |
The human cohort was left unstratified (overall) or was stratified into subjects with low plasma FFA (lowest two quintiles of data distribution combined) and high plasma FFA (highest two quintiles combined) concentrations, respectively (the mid quintile was excluded from analysis as grey zone). Metabolic data were adjusted for gender, age, and BMI. The SNP was analyzed in the additive and dominant inheritance model (padd, pdom). Significant associations (p < 0.0127 after Bonferroni correction for four SNPs) are marked by using bold fonts. AUC – area under the curve; FFA – free fatty acid; IRI-AT – insulin resistance index adipose tissue; ISI-OGTT – insulin sensitivity index oral glucose tolerance test; SNP – single nucleotide polymorphism.