Figure 2.

Activated MILs exert a potent antitumor MILs. (A) NOD/SCID mice (10 mice per group) were challenged with the H929 myeloma cell line and followed until a detectable kappa light chain was present in the blood consistent with engraftment. The mice were challenged with either activated PBLs or activated MILs and followed for overall survival. (B) To determine the ability of these T cells to traffic and exert antimyeloma activity, the mice were sacrificed at the indicated time points. When mice that received aPBL died or conversely a mouse that received aMILs was sacked on D110 to analyze the BM was stained for either human CD3 cells or CD138⁺ myeloma. As shown, the mice that received MILs showed significant T cell trafficking to the BM and no detectable myeloma.