Table 1.
Properties of spontaneous activity in WT and SAC-β2-cKO mice during the first postnatal weeka
Contralateral P2 (n = 3) | cKO P2 (n = 3) | Contralateral P4 (n = 6) | cKO P4 (n = 9) | |
---|---|---|---|---|
Firing rate (Hz) | 0.19 ± 0.12 | 0.19 ± 0.03 | 0.39 ± 0.09 | 0.35 ± 0.16 |
Firing rate in wave (Hz) | 2.99 ± 0.07 | 2.32 ± 0.36 | 3.32 ± 0.43 | 2.99 ± 0.48 |
Wave frequency (per min) | 0.86 ± 0.06 | 0.80 ± 0.05 | 0.78 ± 0.06 | 0.91 ± 0.36 |
Wave duration (s) | 9.66 ± 0.92 | 11.07 ± 0.69 | 12.09 ± 2.05 | 8.71 ± 0.72** |
Wave size (%) | 34.97 ± 6.62 | 24.75 ± 1.04 | 47.82 ± 4.44 | 21.89 ± 6.12*** |
% spikes in burst | 72.37 ± 33.83 | 77.77 ± 29.97 | 81.32 ± 27.79 | 76.82 ± 29.80* |
Burst frequency (per min) | 0.67 ± 0.39 | 0.68 ± 0.34 | 0.81 ± 0.92 | 0.93 ± 0.53* |
Burst duration (s) | 1.27 ± 0.83 | 1.47 ± 0.69* | 2.16 ± 1.03 | 2.12 ± 3.85 |
Interburst interval (s) | 90.68 ± 131.6 | 92.84 ± 85.33 | 83.99 ± 83.15 | 73.33 ± 92.87 |
Interspike interval during burst (s) | 0.14 ± 0.11 | 0.17 ± 0.12* | 0.61 ± 5.16 | 0.64 ± 3.64 |
Firing rate in burst (Hz) | 8.55 ± 4.89 | 7.08 ± 3.81 | 8.59 ± 5.66 | 7.13 ± 4.50*** |
aData are mean ± SD. Cholinergic retinal waves are smaller, with shorter wave duration and a lower firing rate per burst in SAC-β2-cKO mice at P4 than in WT, but waves are more normal at P2 when Cre is expressed in a much smaller proportion of SACs.
*p < 0.05;
**p < 0.01;
***p < 0.001.