Table 2.
Properties of spontaneous retinal activity in SAC-β2-cKO mice on VG1-KO backgrounda
| Contr P8 (n = 5) | DKO P8 (n = 4) | Contr P11 (n = 8) | DKO P11 (n = 9) | |
|---|---|---|---|---|
| Firing rate (Hz) | 0.46 ± 0.14 | 0.43 ± 0.12 | 0.61 ± 0.37 | 0.31 ± 0.32 |
| Firing rate in wave (Hz) | 3.95 ± 0.81 | 3.85 ± 0.15 | 3.92 ± 1.32 | NA |
| Wave frequency (per min) | 0.97 ± 0.37 | 1.55 ± 0.41 | 1.26 ± 0.33 | NA |
| Wave duration (s) | 5.24 ± 0.45 | 9.18 ± 2.18** | 8.06 ± 1.28 | NA |
| Wave size (%) | 48.06 ± 4.39 | 21.98 ± 4.62*** | 50.13 ± 10.82 | NA |
| % spikes in burst | 87.25 ± 19.20 | 85.90 ± 15.13 | 87.11 ± 18.39 | 81.48 ± 15.48*** |
| Burst frequency (per min) | 1.05 ± 0.50 | 1.31 ± 0.74*** | 1.27 ± 0.65 | 1.02 ± 1.14*** |
| Burst duration (s) | 2.70 ± 16.22 | 2.70 ± 16.22 | 2.31 ± 12.7 | 8.61 ± 25.75*** |
| Interburst interval (s) | 62.69 ± 42.66 | 65.07 ± 71.13 | 63.91 ± 79.01 | 116.4 ± 146.7*** |
| Interspike interval during burst (s) | 0.31 ± 2.19 | 0.41 ± 1.98 | 0.28 ± 1.79 | 0.78 ± 3.43*** |
| Firing rate in burst (Hz) | 14.34 ± 8.93 | 15.32 ± 8.22*** | 17.24 ± 10.49 | 10.76 ± 5.83*** |
aData are mean ± SD. NA, Not applicable. Retinal activity mimics cholinergic waves in VG1−/− controls at P8 and P11, but SAC-β2-cKO mice on the VG1−/− background significantly disrupt second week retinal wave duration, size, burst frequency, and firing rate at P8, and drastically disrupt waves at P11.
**p < 0.01;
***p < 0.001.